Many of the genera placed in the Pseudoascobolaceae by Boudier do not show true relationships and were based on the number of asci and ascospores, and other superficial features. Qualitative microscopic and microchemical characters of the asci and ascospores, combined with characters of ascocarp development, cultural features, and cytological aspects will provide a more natural classification of this group. The genera of the Thelebolaceae are discussed.